Synthesis, characterization, and in-vitro antitumor effect of functional group modulated
pH-responsive hydrogel against breast cancer

Mukherjee Arjama

Abstract

Synthesis, characterization, and in-vitro antitumor effect of functional group modulated pH-responsive hydrogel against breast cancer

Hyaluronic acid (HA) is a natural linear polysaccharide having multiple acid and hydroxyl groups which makes it aspH responsive hydroge lby chemical modification. In this present study describes the design and synthesis of pH responsive vitamin E-polyethylene glycol based hyaluronic acid hydrogel. The hydrogel loaded with doxorubicin (DOX) exhibited high loading capacity and the release amount of DOX ascended with pH value decreasing from 7.0 to4.0. Our results suggested that 200nm core-shell hydrogel was formed which caused controlled release of drug under acidic conditions because deformation of hydrogel C–H/N–H group at acidic condition. The cytotoxicity assay demonstrated that DOX loaded VE-PEG-HA-CA hydrogel has much higher cytotoxicity compared to free DOX and better cell uptake due to the hydrogel effect. Drug loaded VE-PEG-HA-CA achieved 83 % regressions of tumor cells and DOX show only 75 % cell death in in vitro model.

Author(s):

Mukherjee Arjama

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